乙二醇二甲醚
乙二醇二甲醚是一种化学品，分子式是C4H10O2。
- 中文名 乙二醇二甲醚
- 外文名 ethylene glycol dimethyl ether;1,2-dimethoxyethane
- 分子式 C4H10O2;CH3OCH2CH2OCH3
- 分子量 90.12
理化常数
国标编号 32093CAS号 110-71-4
中文名称 1，2-二甲氧基乙烷
英文别名:1,2-ethanediol, dimethyl ether; 2,5-Dioxahexane; alpha,beta-dimethoxyethane; ansul ether 121; Dimethoxyethane; Dimethyl Cellosolve; DME; EGDME; ethylene dimethyl ether; Ethylene glycol dimethyl ether; GDME; Glycol dimethyl ether; Glyme; monoethylene glycol dimethyl ether; Monoglyme; MONOETHYLENGLYCOL; 1,2-dimethoxy-ethan; 1,2-Ethanediol dimethyl ether; 1,2-ethanediol,dimethylether; Ansol E-121; ansulether121; CH3OCH2CH2OCH3; dimethylcellosolvesolvent; Dimethylcollosolve
中文别名:乙二醇二甲醚;二甲基溶纤剂1,2-二甲氧基乙烷; 1,2-二甲氧基代乙烷; 1,2-二甲基乙烷;
蒸汽压 6.40kPa/20℃ 闪点:1℃/开杯
熔 点 -69℃ 沸点:83℃ 溶解性 溶于水、烃类
密 度 相对密度(水=1)0.87;
相对密度(空气=1)3.11 稳定性 稳定
术语分类
安全性
S45In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
若发生事故或感不适，立即就医(可能的话，出示其标签)。
S53Avoid exposure - obtain special instructions before use.
避免接触，使用前须获得特别指示说明。
危险性
R11Highly flammable.
高度易燃。
R19May form explosive peroxides.
可能生成爆炸性过氧化物。
R20Harmful by inhalation.
吸入有害。
R60May impair fertility.
可能损害生育能力。
R61May cause harm to the unborn child.
可能对胎儿造成伤害。
危险标记 7(中闪点易燃液体) 主要用途 用作溶剂、医药抽提剂、有机合成中间体。
制作麻醉药的主要成分。
乙二醇二甲醚(DME)是一种带有醚味的水白色中性液体，性质稳定，不易发生反应，能溶解各种树脂和纤维素，并能与水和许多醇，酮，酯等有机溶剂以任意比例混溶，其溶解能力可以通过水或某些溶剂作适当稀释来调节。DME是一种性能优良的非质子极性溶剂，除了用作气体吸收剂，萃取剂和脱漆剂外，还可以用于以下化学领域。用于电化学:由于DME的特殊结构，可替代水作非水溶液电解质溶剂，用于电化学设备，充电电池及有机化合物电解反应等。比如:苯，四丁基溴化铵，DME的水溶液体系进行电解反应，可制得纯度为百分之九十六的1,4二羟基苯。制备硼化学: DME作为溶剂，可用于制得硼，硼氢化物，多硼氢化合物，多硼氢酸盐等多种硼衍生物。比如;三烷基硼化物和氢化铝钠在DME中反应，制得的硼氢化钠纯度高，颗粒大。制备有机金属化合物: DME是有机金属反应的重要试剂，可用于制备锑，硒，锡，钛，铼，铁，钌等有机金属化合物。用于高分子材料的聚合反应;用作清洗剂复配物;用于有机化合物及医药中间体的合成等。
环境影响
健康危害
侵入途径:吸入、食入、经皮吸收。
健康危害:口服引起恶心、呕吐、腹绞痛、虚弱、昏迷。具有刺激性。
刺激性:家兔经眼:50mg，中度刺激。家兔经皮开放性刺激试验:500mg，轻度刺激。
环境行为
危险特性:易燃，遇明火、高热易引起燃烧爆炸。与氧化剂能发生强烈反应。接触空气或在光照条件下可生成具有潜在爆炸危险性的过氧化物。其蒸气比空气重，能在较低处扩散到相当远的地方，遇明火会引着回燃。
燃烧(分解)产物:一氧化碳、二氧化碳。
应急处理
防护措施
迅速撤离泄漏污染区人员至安全区，并进行隔离，严格限制出入。切断火源。建议应急处理人员戴自给正压式呼吸器，穿消防防护服。尽可能切断泄漏源，防止进入下水道、排洪沟等限制性空间。小量泄漏:用活性炭或其它惰性材料吸收。也可以用大量水冲洗，洗水稀释后放入废水系统。大量泄漏:构筑围堤或挖坑收容;用泡沫覆盖，降低蒸气灾害。用防爆泵转移至槽车或专用收集器内，回收或运至废物处理场所处置。
呼吸系统防护:高浓度蒸气接触可佩戴过滤式防毒面具(半面罩)。
眼睛防护:一般不需要特殊防护，高浓度接触时可戴化学安全防护眼镜。
身体防护:穿防静电工作服。
手防护:戴乳白色胶手套。
其它:工作现场禁止吸烟、进食和饮水。工作毕，淋浴更衣。注意个人清洁卫生。
急救措施
皮肤接触:脱去被污染的衣着，用肥皂水和清水彻底冲洗皮肤。
眼睛接触:提起眼睑，用流动清水或生理盐水冲洗。就医。
吸入:迅速脱离现场至空气新鲜处。保持呼吸道通畅。如呼吸困难，给输氧。如呼吸停止，立即进行人工呼吸。就医。
食入:饮足量温水，催吐，就医。
灭火方法:尽可能将容器从火场移至空旷处。喷水保持火场容器冷却，直至灭火结束。处在火场中的容器若已变色或从安全泄压装置中产生声音，必须马上撤离。灭火剂:抗溶性泡沫、干粉、二氧化碳、砂土。
物质毒性
编号 | 毒性类型 | 测试方法 | 测试对象 | 使用剂量 | 毒性作用 |
1 | acute | Oral | Human | 3380 mg/kg | 1.胃肠道毒性Gastrointestinal - gastritis 2.肝毒性Liver - other changes 3.肾、输尿管和膀胱毒性Kidney, Ureter, Bladder -other changes |
2 | acute | Inhalation | Human | 25 ppm | 1.行为毒性Behavioral - tremor 2.行为毒性Behavioral - convulsions or effect on seizure threshold 3.行为毒性Behavioral - changes in motor activity (specific assay) |
3 | acute | Oral | Rodent - rat | 2370 mg/kg | 1.行为毒性Behavioral - altered sleep time (including change in righting reflex) 2.肺部、胸部或者呼吸毒性Lungs, Thorax, or Respiration -other changes |
4 | acute | Inhalation | Rodent - rat | 1500 ppm/7H | 1.Details of toxic effects not reported other than lethal dose value |
5 | acute | Intraperitoneal | Rodent - rat | 2500 mg/kg | 1.Details of toxic effects not reported other than lethal dose value |
6 | acute | Intravenous | Rodent - rat | 2068 mg/kg | 1.血液毒性Blood - other hemolysis with or without anemia |
7 | acute | Oral | Rodent - mouse | 2560 mg/kg | 1.行为毒性Behavioral - somnolence (general depressed activity) 2.行为毒性Behavioral - changes in motor activity (specific assay) 3.心脏毒性Cardiac - other changes |
8 | acute | Inhalation | Rodent - mouse | 1480 ppm/7H | 1.行为毒性Behavioral - analgesia 2.肺部、胸部或者呼吸毒性Lungs, Thorax, or Respiration -dyspnea 3.肾、输尿管和膀胱毒性Kidney, Ureter, Bladder -hematuria |
9 | acute | Intraperitoneal | Rodent - mouse | 2147 mg/kg | 1.肾、输尿管和膀胱毒性Kidney, Ureter, Bladder -changes in both tubules and glomeruli 2.血液毒性Blood - changes in spleen 3.血液毒性Blood - other changes |
10 | acute | Oral | Rodent - rabbit | 890 mg/kg | 1.行为毒性Behavioral - general anesthetic 2.血液毒性Blood - other hemolysis with or without anemia |
11 | acute | Administration onto the skin | Rodent - rabbit | 1280 mg/kg | 1.Details of toxic effects not reported other than lethal dose value |
12 | acute | Oral | Rodent - guinea pig | 950 mg/kg | 1.行为毒性Behavioral - general anesthetic 2.胃肠道毒性Gastrointestinal - other changes 3.肾、输尿管和膀胱毒性Kidney, Ureter, Bladder -other changes |
13 | MutipleDose | Inhalation | Rodent - rat | 400 ppm/6H/2W-I | 1.大脑毒性Brain and Coverings - other degenerative changes 2.营养和代谢系统毒性Nutritional and Gross Metabolic - weight loss or decreased weight gain 3.生化毒性Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - multiple enzyme effects |
14 | MutipleDose | Oral | Rodent - rat | 10206 mg/kg/21D-C | 1.内分泌毒性Endocrine - changes in thymus weight 2.营养和代谢系统毒性Nutritional and Gross Metabolic - weight loss or decreased weight gain 3.慢性病相关毒性Related to Chronic Data - changes in testicular weight |
15 | MutipleDose | Oral | Rodent - rat | 500 mg/kg/10D-I | 1.内分泌毒性Endocrine - changes in thymus weight 2.免疫系统毒性Immunological Including Allergic - decreased immune response |
16 | MutipleDose | Inhalation | Rodent - rat | 300 ppm/6H/13W-I | 1.血液毒性Blood - changes in leukocyte (WBC) count 2.营养和代谢系统毒性Nutritional and Gross Metabolic - weight loss or decreased weight gain 3.慢性病相关毒性Related to Chronic Data - changes in testicular weight |
17 | MutipleDose | Inhalation | Rodent - rat | 970 mg/m3/7H/5W-I | 1.血液毒性Blood - changes in bone marrow (not otherwise specified) 2.血液毒性Blood - changes in spleen |
18 | MutipleDose | Inhalation | Rodent - rat | 1000 ppm/6H/11D-I | 1.肾、输尿管和膀胱毒性Kidney, Ureter, Bladder -other changes in urine composition 2.血液毒性Blood - changes in bone marrow (not otherwise specified) 3.血液毒性Blood - changes in leukocyte (WBC) count |
19 | MutipleDose | Administration onto the skin | Rodent - rat | 20 mg/kg/4W-I | 1.血液毒性Blood - changes in other cell count (unspecified) 2.血液毒性Blood - changes in leukocyte (WBC) count 3.慢性病相关毒性Related to Chronic Data - changes in testicular weight |
20 | MutipleDose | Intraperitoneal | Rodent - rat | 450 mg/kg/16D-I | 1.血液毒性Blood - changes in other cell count (unspecified) 2.生化毒性Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - other Enzymes |
21 | MutipleDose | Oral | Rodent - rat | 29484 mg/kg/13W-C | 1.内分泌毒性Endocrine - changes in thymus weight 2.血液毒性Blood - changes in platelet count 3.营养和代谢系统毒性Nutritional and Gross Metabolic - weight loss or decreased weight gain |
22 | MutipleDose | Administration onto the skin | Rodent - rat | 3200 mg/kg/4D-I | 1.内分泌毒性Endocrine - changes in thymus weight 2.免疫系统毒性Immunological Including Allergic - decrease in humoral immune response |
23 | MutipleDose | Oral | Rodent - mouse | 12110 mg/kg/2W-C | 1.内分泌毒性Endocrine - changes in thymus weight 2.慢性病相关毒性Related to Chronic Data - changes in testicular weight |
24 | MutipleDose | Oral | Rodent - mouse | 82 mg/kg/13W-C | 1.内分泌毒性Endocrine - effect on menstrual cycle 2.内分泌毒性Endocrine - other changes 3.血液毒性Blood - changes in spleen |
25 | MutipleDose | Inhalation | Rodent - mouse | 1000 ppm/6H/11D-I | 1.血液毒性Blood - changes in leukocyte (WBC) count 2.慢性病相关毒性Related to Chronic Data - changes in testicular weight |
26 | MutipleDose | Inhalation | Mammal - dog | 750 ppm/7H/12W-I | 1.血液毒性Blood - microcytosis with or without anemia 2.血液毒性Blood - other changes |
27 | MutipleDose | Inhalation | Rodent - rabbit | 300 ppm/6H/13W-I | 1.内分泌毒性Endocrine - changes in thymus weight 2.血液毒性Blood - changes in erythrocyte (RBC) count 3.慢性病相关毒性Related to Chronic Data - changes in testicular weight |
28 | MutipleDose | Administration onto the skin | Rodent - guinea pig | 65 mg/kg/13W-I | 1.血液毒性Blood - changes in erythrocyte (RBC) count 2.营养和代谢系统毒性Nutritional and Gross Metabolic - weight loss or decreased weight gain 3.慢性病相关毒性Related to Chronic Data - changes in testicular weight |
29 | SkinEyeIrrition | Administration onto the skin | Rodent - rabbit | 483 mg/24H | 1.Mild |
30 | SkinEyeIrrition | Administration into the eye | Rodent - rabbit | 97 mg | |
31 | SkinEyeIrrition | Administration into the eye | Rodent - rabbit | 500 mg/24H | 1.Mild |
32 | SkinEyeIrrition | Administration into the eye | Rodent - guinea pig | 10 ug | 1.Mild |
33 | Mutation | Human Lymphocyte | 150 mmol/L | ||
34 | Mutation | Oral | Rodent - rat | 500 mg/kg | |
35 | Mutation | Oral | Rodent - rat | 500 mg/kg | |
36 | Mutation | Oral | Rodent - mouse | 500 mg/kg | |
37 | Reproductive | Oral | Rodent - rat | 175 mg/kg,female 7-13 day(s) after conception | 1.生殖毒性Reproductive - Specific Developmental Abnormalities -cardiovascular (circulatory) system |
38 | Reproductive | Oral | Rodent - rat | 175 mg/kg,female 7-13 day(s) after conception | 1.生殖毒性Reproductive - Maternal Effects - parturition 2.生殖毒性Reproductive - Effects on Newborn -biochemical and metabolic |
39 | Reproductive | Oral | Rodent - rat | 15015 mg/kg,male 13 week(s) pre-mating | 1.生殖毒性Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, andcount) |
40 | Reproductive | Oral | Rodent - rat | 100 mg/kg,male 1 day(s) pre-mating | 1.生殖毒性Reproductive - Paternal Effects - testes, epididymis, spermduct |
41 | Reproductive | Oral | Rodent - rat | 350 mg/kg,female 9-15 day(s) after conception | 1.生殖毒性Reproductive - Fertility -litter size (e.g. # fetuses per litter; measured before birth) 2.生殖毒性Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stuntedfetus) 3.生殖毒性Reproductive - Specific Developmental Abnormalities -cardiovascular (circulatory) system |
42 | Reproductive | Inhalation | Rodent - rat | 68 mg/kg/4H,female 1-19 day(s) after conception | 1.生殖毒性Reproductive - Fertility -pre-implantation mortality (e.g. reduction in number of implants per female; total number of implants per corpora lutea) 2.生殖毒性Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) |
43 | Reproductive | Inhalation | Rodent - rat | 30 ppm/6H,male 65 day(s) pre-mating | 1.生殖毒性Reproductive - Paternal Effects - testes, epididymis, spermduct |
44 | Reproductive | Inhalation | Rodent - rat | 100 ppm/6H,female 6-17 day(s) after conception | 1.生殖毒性Reproductive - Maternal Effects - parturition 2.生殖毒性Reproductive - Fertility -female fertility index (e.g. # females pregnant per # sperm positive females; # females pregnant per # femalesmated) 3.生殖毒性Reproductive- Effects on Newborn -live birth index (measured after birth) |
45 | Reproductive | Inhalation | Rodent - rat | 100 ppm/6H,female 6-17 day(s) after conception | 1.生殖毒性Reproductive - Effects on Newborn -viability index (e.g., # alive at day 4 per # bornalive) 2.生殖毒性Reproductive - Effects on Newborn -growth statistics (e.g.%, reduced weight gain) |
46 | Reproductive | Inhalation | Rodent - rat | 30 ppm/6H,male 13 week(s) pre-mating | 1.生殖毒性Reproductive - Fertility -post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) |
47 | Reproductive | Administration onto the skin | Rodent - rat | 11592 mg/kg,female 6-17 day(s) after conception | 1.生殖毒性Reproductive - Fertility -female fertility index (e.g. # females pregnant per # sperm positive females; # females pregnant per # femalesmated) 2.生殖毒性Reproductive - Effects on Embryo or Fetus - fetaldeath |
48 | Reproductive | Administration onto the skin | Rodent - rat | 4375 mg/kg,male 7 day(s) pre-mating | 1.生殖毒性Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, andcount) 2.生殖毒性Reproductive - Paternal Effects - testes, epididymis, spermduct 3.生殖毒性Reproductive - Fertility - male fertility index (e.g. # males impregnating females per # males exposed to fertile nonpregnant females) |
49 | Reproductive | Administration onto the skin | Rodent - rat | 2 mg/kg,female 10 day(s) after conception | 1.生殖毒性Reproductive - Fertility -post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) |
50 | Reproductive | Administration onto the skin | Rodent - rat | 1 mg/kg,female 12 day(s) after conception | 1.生殖毒性Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stuntedfetus) 2.生殖毒性Reproductive - Specific Developmental Abnormalities -craniofacial (including nose andtongue) 3.生殖毒性Reproductive - Specific Developmental Abnormalities -gastrointestinal system |
51 | Reproductive | Intraperitoneal | Rodent - rat | 330 mg/kg,female 12 day(s) after conception | 1.生殖毒性Reproductive - Specific Developmental Abnormalities -musculoskeletal system 2.生殖毒性Reproductive - Specific Developmental Abnormalities -cardiovascular (circulatory) system |
52 | Reproductive | Intraperitoneal | Rodent - rat | 190 mg/kg,female 14 day(s) after conception | 1.生殖毒性Reproductive - Specific Developmental Abnormalities -Central Nervous System 2.生殖毒性Reproductive - Specific Developmental Abnormalities -urogenital system |
53 | Reproductive | Intraperitoneal | Rodent - rat | 190 mg/kg,female 12 day(s) after conception | 1.生殖毒性Reproductive - Specific Developmental Abnormalities -musculoskeletal system |
54 | Reproductive | Intraperitoneal | Rodent - rat | 190 mg/kg,female 8 day(s) after conception | 1.生殖毒性Reproductive - Fertility -post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) |
55 | Reproductive | Subcutaneous | Rodent - rat | 600 mg/kg,female 6-20 day(s) after conception | 1.生殖毒性Reproductive- Effects on Newborn -live birth index (measured after birth) 2.生殖毒性Reproductive - Effects on Newborn -viability index (e.g., # alive at day 4 per # bornalive) |
56 | Reproductive | Subcutaneous | Rodent - rat | 440 mg/kg,female 7-17 day(s) after conception | 1.生殖毒性Reproductive- Effects on Newborn -live birth index (measured after birth) |
57 | Reproductive | Oral | Rodent - rat | 250 mg/kg,female 13 day(s) after conception | 1.生殖毒性Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stuntedfetus) 2.生殖毒性Reproductive - Specific Developmental Abnormalities -musculoskeletal system |
58 | Reproductive | Oral | Rodent - mouse | 175 mg/kg,female 11 day(s) after conception | 1.生殖毒性Reproductive - Specific Developmental Abnormalities -musculoskeletal system |
59 | Reproductive | Oral | Rodent - mouse | 2 mg/kg,female 7-14 day(s) after conception | 1.生殖毒性Reproductive - Fertility -litter size (e.g. # fetuses per litter; measured before birth) 2.生殖毒性Reproductive - Effects on Embryo or Fetus - fetaldeath 3.生殖毒性Reproductive - Specific Developmental Abnormalities -Central Nervous System |
60 | Reproductive | Oral | Rodent - mouse | 500 mg/kg,female 9 day(s) after conception | 1.生殖毒性Reproductive - Fertility -post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) 2.生殖毒性Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured before birth) 3.生殖毒性Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stuntedfetus) |
61 | Reproductive | Oral | Rodent - mouse | 250 mg/kg,female 11 day(s) after conception | 1.生殖毒性Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stuntedfetus) 2.生殖毒性Reproductive - Specific Developmental Abnormalities -musculoskeletal system |
62 | Reproductive | Oral | Rodent - mouse | 6250 mg/kg,male 25 day(s) pre-mating | 1.生殖毒性Reproductive - Paternal Effects - testes, epididymis, spermduct |
63 | Reproductive | Inhalation | Rodent - mouse | 1000 ppm/6H,male 11 day(s) pre-mating | 1.生殖毒性Reproductive - Paternal Effects - testes, epididymis, spermduct |
64 | Reproductive | Inhalation | Rodent - mouse | 500 ppm/7H,male 5 day(s) pre-mating | 1.生殖毒性Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, andcount) |
65 | Reproductive | Inhalation | Rodent - mouse | 50 ppm/6H,female 6-15 day(s) after conception | 1.生殖毒性Reproductive - Fertility -litter size (e.g. # fetuses per litter; measured before birth) 2.生殖毒性Reproductive - Specific Developmental Abnormalities -urogenital system |
66 | Reproductive | Inhalation | Rodent - mouse | 50 ppm/6H,female 6-15 day(s) after conception | 1.生殖毒性Reproductive - Specific Developmental Abnormalities -musculoskeletal system 2.生殖毒性Reproductive - Specific Developmental Abnormalities -urogenital system |
67 | Reproductive | Subcutaneous | Rodent - mouse | 1200 mg/kg,female 7-13 day(s) after conception | 1.生殖毒性Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stuntedfetus) |
68 | Reproductive | Subcutaneous | Rodent - mouse | 3200 mg/kg,female 7-14 day(s) after conception | 1.生殖毒性Reproductive - Fertility -post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) |
69 | Reproductive | Subcutaneous | Rodent - mouse | 250 mg/kg,female 8 day(s) after conception | 1.生殖毒性Reproductive - Specific Developmental Abnormalities -Central Nervous System 2.生殖毒性Reproductive - Specific Developmental Abnormalities -craniofacial (including nose andtongue) |
70 | Reproductive | Intravenous | Rodent - mouse | 250 mg/kg,female 8 day(s) after conception | 1.生殖毒性Reproductive - Specific Developmental Abnormalities -Central Nervous System |
71 | Reproductive | Oral | Primate - monkey | 930 mg/kg,female 20-45 day(s) after conception | 1.生殖毒性Reproductive - Fertility -abortion 2.生殖毒性Reproductive - Effects on Embryo or Fetus - fetaldeath |
72 | Reproductive | Oral | Primate - monkey | 633 mg/kg,female 20-45 day(s) after conception | 1.生殖毒性Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stuntedfetus) |
73 | Reproductive | Inhalation | Rodent - rabbit | 300 ppm/6H,male 65 day(s) pre-mating | 1.生殖毒性Reproductive - Paternal Effects - testes, epididymis, spermduct |
74 | Reproductive | Inhalation | Rodent - rabbit | 50 ppm/6H,female 6-18 day(s) after conception | 1.生殖毒性Reproductive - Specific Developmental Abnormalities -body wall 2.生殖毒性Reproductive - Specific Developmental Abnormalities -cardiovascular (circulatory) system 3.生殖毒性Reproductive - Specific Developmental Abnormalities -urogenital system |
75 | Reproductive | Inhalation | Rodent - rabbit | 50 ppm/6H,female 6-18 day(s) after conception | 1.生殖毒性Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stuntedfetus) 2.生殖毒性Reproductive - Specific Developmental Abnormalities -body wall 3.生殖毒性Reproductive - Specific Developmental Abnormalities -musculoskeletal system |
76 | Reproductive | Inhalation | Rodent - rabbit | 10 ppm/6H,female 6-18 day(s) after conception | 1.生殖毒性Reproductive - Fertility -post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) 2.生殖毒性Reproductive - Specific Developmental Abnormalities -musculoskeletal system |
77 | Reproductive | Oral | Rodent - guinea pig | 6250 mg/kg,male 25 day(s) pre-mating | 1.生殖毒性Reproductive - Paternal Effects - testes, epididymis, spermduct |
78 | Reproductive | Administration onto the skin | Rodent - guinea pig | 65 mg/kg,male 65 day(s) pre-mating | 1.生殖毒性Reproductive - Paternal Effects - testes, epididymis, spermduct |
79 | Reproductive | Oral | Rodent - hamster | 1562 mg/kg,male 25 day(s) pre-mating | 1.生殖毒性Reproductive - Paternal Effects - testes, epididymis, spermduct |