熊 伟，教授，博士生导师。国家中组部“青年千人计画”获得者。
人物简介
2001年毕业于北京大学生命科学学院，获理学学士学位。
2006年毕业于北京大学生命科学学院，获理学博士学位。
2006至2013年，在美国国立卫生研究院（NIH）酒精滥用与酒精中毒研究所（NIAAA）做博士后研究工作。
2013年3月加入中国科学技术大学生命科学学院。
研究方向
长期从事与药物镇痛、耐受和成瘾有关的神经生物学研究，并运用多种先进的实验技术对该问题从分子、细胞水平、到动物行为进行了完整的深入系统的研究，并取得了系列重要成果。研究工作发表在Nature Chemical Biology, Journal of Experimental Medicine, Journal of Neuroscience, Molecular Pharmacology等国际学术期刊上。文章被美国药物依赖研究所（NIDA）评选为“FEATURED PAPER OF THE MONTH”。曾获得2011年度美国国立卫生研究院颁发给优秀研究人员的奖项“Fellows Award for Research Excellence”。
研究课题
（1） 离子通道受体的调节机制及相关小分子药物的设计与合成
（2） 配体门控型离子通道受体与药物镇痛、耐受和成瘾的关係
（3） 突触前离子通道受体的发育与调节机制
（2） 配体门控型离子通道受体与药物镇痛、耐受和成瘾的关係
（3） 突触前离子通道受体的发育与调节机制
代表论文
1.Wei Xiong, KeJun Chen, Tanxing Cui, Grzegorz Godlewski, Kenner Rice, Yan Xu and Li Zhang. Cannabinoid potentiation of glycine receptors contributes to cannabis-induced analgesia. Nature Chemical Biology, 7: 296-303 (2011).
Also see NEWS AND VIEWS: Receptors: Cannabis medicine without a high. MacDonald J Christie & Christopher E Vaughan. Nature Chemical Biology, 7:249-250 (2011)
Research Highlight: Nature Reviews Neuroscience 12: 306 (2011)
Commented and rated as ‘Must Read” by Faculty of 1000 (2011)
2.Wei Xiong, Tanxing Cui, Kejun Cheng, Fei Yang, Shao-Rui Chen, Dan Willenbring, Yun Guan, Hui-Lin Pan, Ke Ren, Yan Xu and Li Zhang. Cannabinoids suppress inflammatory and neuropathic pain by targeting α3 glycine receptors. Journal of Experimental Medicine, 209 (6): 1121-1134 (2012)
3.Wei Xiong, Xiongwu Wu, David M. Lovinger and Li Zhang. A Common Molecular Basis for Exogenous and Endogenous Cannabinoid Potentiation of Glycine Receptors. Journal of Neuroscience, 32 (15): 5200-5208 (2012)
4.Wei Xiong, Masako Hosoi, Bon-Nyeo Koo, and Li Zhang. Anandamide Inhibition of 5-HT3A Receptors Varies with Receptor Density and Desensitization. Molecular Pharmacology, 73:314-322 (2008)
5.Wei Xiong, Bon-Nyeo Koo, Russell Morton and Li Zhang. Psychotropic and nonpsychotropic cannabis derivatives inhibit human 5-HT3A receptors through a receptor desensitization-dependent mechanism. Neuroscience,184: 28-37 (2011)
6.Wei Xiong, Long-Chuan Yu. Involvement of endogenous cholecystokinin in morphine tolerance in the nucleus accumbens of rats. Behavioural Brain Research (IF≈3.5), 173:116-121 (2006).
7.Yan Zhang, Wei Xiong, Xiaojin Lin, Xiang Ma and Long-Chuan Yu. Receptor trafficking induced by μ-opioid-receptor phosphorylation. Neuroscience & Biobehavioral Reviews, 33: 1192-1197 (2009)
8.Cecilia M. Borghese, Wei Xiong, S. Irene Oh, Angel Ho, John Mihic, Li Zhang, David M. Lovinger and Gregg E. Homanics. Mutations M287L and Q266I in the glycine receptor alpha1 subunit change sensitivity to volatile anesthetics in oocytes and neurons, but Not the minimal alveolar concentration in Knockin Mice. Anesthesiology, 17(4):765-71. (2012)
9.Cecilia M. Borghese, Yuri A. Blednov, Yu Quan, Sangeetha V. Iyer, Wei Xiong, S. John Mihic, Li Zhang, David M. Lovinger, James R. Trudell, Gregg E. Homanics, R. Adron Harris. Characterization of Two Mutations, M287L and Q266I, in the α1 Glycine Receptor Subunit That Modify Sensitivity to Alcohols. Journal of Pharmacology and Experimental Therapeutics, 340: 304-316 (2012)
Also see NEWS AND VIEWS: Receptors: Cannabis medicine without a high. MacDonald J Christie & Christopher E Vaughan. Nature Chemical Biology, 7:249-250 (2011)
Research Highlight: Nature Reviews Neuroscience 12: 306 (2011)
Commented and rated as ‘Must Read” by Faculty of 1000 (2011)
2.Wei Xiong, Tanxing Cui, Kejun Cheng, Fei Yang, Shao-Rui Chen, Dan Willenbring, Yun Guan, Hui-Lin Pan, Ke Ren, Yan Xu and Li Zhang. Cannabinoids suppress inflammatory and neuropathic pain by targeting α3 glycine receptors. Journal of Experimental Medicine, 209 (6): 1121-1134 (2012)
3.Wei Xiong, Xiongwu Wu, David M. Lovinger and Li Zhang. A Common Molecular Basis for Exogenous and Endogenous Cannabinoid Potentiation of Glycine Receptors. Journal of Neuroscience, 32 (15): 5200-5208 (2012)
4.Wei Xiong, Masako Hosoi, Bon-Nyeo Koo, and Li Zhang. Anandamide Inhibition of 5-HT3A Receptors Varies with Receptor Density and Desensitization. Molecular Pharmacology, 73:314-322 (2008)
5.Wei Xiong, Bon-Nyeo Koo, Russell Morton and Li Zhang. Psychotropic and nonpsychotropic cannabis derivatives inhibit human 5-HT3A receptors through a receptor desensitization-dependent mechanism. Neuroscience,184: 28-37 (2011)
6.Wei Xiong, Long-Chuan Yu. Involvement of endogenous cholecystokinin in morphine tolerance in the nucleus accumbens of rats. Behavioural Brain Research (IF≈3.5), 173:116-121 (2006).
7.Yan Zhang, Wei Xiong, Xiaojin Lin, Xiang Ma and Long-Chuan Yu. Receptor trafficking induced by μ-opioid-receptor phosphorylation. Neuroscience & Biobehavioral Reviews, 33: 1192-1197 (2009)
8.Cecilia M. Borghese, Wei Xiong, S. Irene Oh, Angel Ho, John Mihic, Li Zhang, David M. Lovinger and Gregg E. Homanics. Mutations M287L and Q266I in the glycine receptor alpha1 subunit change sensitivity to volatile anesthetics in oocytes and neurons, but Not the minimal alveolar concentration in Knockin Mice. Anesthesiology, 17(4):765-71. (2012)
9.Cecilia M. Borghese, Yuri A. Blednov, Yu Quan, Sangeetha V. Iyer, Wei Xiong, S. John Mihic, Li Zhang, David M. Lovinger, James R. Trudell, Gregg E. Homanics, R. Adron Harris. Characterization of Two Mutations, M287L and Q266I, in the α1 Glycine Receptor Subunit That Modify Sensitivity to Alcohols. Journal of Pharmacology and Experimental Therapeutics, 340: 304-316 (2012)
