1987年至2000年就读于中国科学技术大学生物系和生命科学学院并先后获学士、硕士和博士学位。

2000年至2003年在法国科研中心及巴黎南大学从事博士后研究。

2004年1月任中国科学技术大学教授，合肥微尺度物质科学国家实验室研究员，同年获中国科学院百人计画择优支持。

2006年至2010年任科技部重大研究计画项目首席科学家，

2009年3月至2014年5月任中国科学技术大学生命科学学院副院长，

2014年5月起任中国科学技术大学教务处处长，

2019年4月起任中国科学技术大学校长助理、教务长。

长期从事本科生“生物化学”教学和研究生培养，现主要研究方向为蓝藻水华的形成机制和干预策略。已在PNAS、Nature子刊、EMBO Reports和JBC等发表研究论文近100篇。

2005年至2017年任中国生物化学与分子生物学学会常务理事，

2014年起任安徽省生物化学与分子生物学学会理事长，

2015年任亚洲及大洋洲生物化学家与分子生物学家联盟（FAOBMB）中国代表，

2015年起任科技部重点研发计画“蛋白质机器与生命过程调控”重点专项指南编写专家组成员,

2017年起任科技部重点研发计画总体专家组成员。

2017年任中国晶体学会副监事长和中国生物化学与分子生物学学会监事。

1、蓝藻水华形成和的分子机理和干预策略

2、噬藻体组装和特异性侵染宿主的分子机制

3、蓝藻碳氮代谢平衡调控的分子机理

1) Structural basis for the allosteric control of the global transcription factor NtcA by the nitrogen starvation signal 2-oxoglutarate. - Proc Natl Acad Sci USA. - 2010 - 107(28)

2) Neofunctionalization of zona pellucida proteins enhances freeze-prevention in the eggs of Antarctic notothenioids - Nature Communications - - 2041-1723

3) Structural Insights into SraP-Mediated Staphylococcus aureus Adhesion to Host Cells - PLoS Pathogens - - 1553-7366

4) Structures of yeast glutathione S-transferase Gtt2 reveal a new catalytic type of GST family - EMBO Reports - 2009 -

5) Structural basis for receptor recognition and pore formation of a zebrafish aerolysin-like protein - EMBO REPORTS - - 1469-221X

6) Structures of an all-α protein running along the DNA major groove - NUCLEIC ACIDS RESEARCH - - 0305-1048

7) Crystal structure and computational analyses provide insights into the catalytic mechanism of 2, 4-diacetylphloroglucinol hydrolase PhlG from Pseudomonas fluorescens. - J Biol Chem. - 2010 - 285(7)

8) Structural plasticity of the thioredoxin recognition site of yeast methionine-S-sulfoxide reductase Mxr1 - JOURNAL OF BIOLOGICAL CHEMISTRY - - 0021-9258

9) Recognition of the Thomsen-Friedenreich Pancarcinoma carbohydrate antigen by a lamprey variable lymphocyte receptor - JOURNAL OF BIOLOGICAL CHEMISTRY - - 0021-9258

10) Structure and Catalytic Mechanism of Yeast 4-Amino-4-deoxychorismate Lyase - JOURNAL OF BIOLOGICAL CHEMISTRY - - 0021-9258

11) Crystal Structure of the Cyanobacterial Signal Transduction Protein P(II) in Complex with PipX - JOURNAL OF MOLECULAR BIOLOGY - - 0022-2836

12) Structural and biochemical characterization of yeast monothiol glutaredoxin Grx6. - J Mol Biol. - 2010 - 398(4)

13) Crystal structure of cyanobacterial signal transduction protein PII in complex with PipX. - J Mol Biol. - 2010 -

14) Systematic cloning and analysis of autophagy-related genes from the silkworm Bombyx mori - BMC Mol Biol. - 2009 -

15) Crystal structure of Saccharomyces cerevisiae glutamine synthetase Gln1 suggests a nanotube-like supramolecular assembly - Proteins - 2009 -

16) Structural basis for the unique anti-tumor activity of LZ-8 from the fungus Ganoderma lucidium - Proteins - 2009 -

17) Crystal structure of the dimeric Urm1 from the yeast Saccharomyces cerevisiae - Proteins - 2008 -

18) Crystal structure of glutathione-dependent phospholipid peroxidase Hyr1 from the yeast Saccharomyces cerevisiae - Proteins - 2008 - 73

19) Glutathionylation-triggered conformational changes of glutaredoxin Grx1 from the yeast Saccharomyces cerevisiae. - Proteins - 2008 -

20) Crystal structure of the yeast cytoplasmic thioredoxin Trx2. - Proteins - 2007 -

21) Crystal structure of glutathione reductase Glrl from the yeast Saccharomyces cerevisiae - Proteins - 2007 -

22) Crystal structure of Saccharomyces cerevisiae 6-phosphogluconate dehydrogenase Gnd1 - BMC Struct Biol. - 2007 -

23) The gene expression profile of Bombyx mori silkgland - Gene - 2007 -

24) Solution structure and metal binding properties of Kti11p from Saccharomyces cerevisiae - Biochemistry - 2005 -

25) Developments in structural genomics:protein purification and function interpertation. - Current Genomics - 2004 -

26) The 62-kb upstream region of Bombyx mori fibroin heavy chain gene is clustered of erpetitive element - GENE - 2003 -

27) Crystal structure of the yeast PX-domain protein Grd19p complexed to phosphatidyl-inositol-3-ph osph - J Biol Chem. - 2003 -

28) Silk fibroin:Structural implications of a remarkable amino acid sequence(SCI) - PROTEINS - 2001 -

29) Identification and characterization of a silkgland-related matrix association ergion in Bombyx mori( - Gene - 2001 -

30) Fine organization of Bombyx mori fibroin heavy chain gene(SCI) - Nucleic Acids Research - 2000 -